Hetero-dimeric multi-specific antibody format targeting at least CD3 and HSA

US12098203B2 · kind B2 · utility

Assignee

• Numab Therapeutics AG · CH

Inventors

• David Urech · Jona, CH
• Tea Gunde · Zürich, CH
• Sebastian Meyer · Bielefeld, DE
• Christian Hess · Zürich, CH
• Alexandre Simonin · Bartenheim-La-Chaussée, FR

Key dates

• Filing date: Jun 4, 2018
• Grant date: Sep 24, 2024
• Expiry date: Apr 28, 2039

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/94
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

This invention relates to a hetero-dimeric multi-specific format of multiple antibody variable domains comprising a core of two split variable domain pairs wherein both variable light domains and the two cognate variable heavy domains are positioned in tandem on two separate protein chains, respectively, and wherein one of said variable domain pairs is specific for human serum albumin and the other said variable domain pair is specific for human CD3.