Compositions and methods for differential Cas9 gene labeling and/or editing
US12098381B2 · kind B2 · utility
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9Claims
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Key dates
| Filing date | Mar 12, 2021 |
| Grant date | Sep 24, 2024 |
| Priority date | — |
| Expiry date | Sep 4, 2042 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2740/15043
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present disclosure relates to methods of and systems for modifying the transcriptional regulation of stem or progenitor cells to promote their differentiation or reprogramming of somatic cells. Further, the labeling and editing of human genomic loci in live cells with three orthogonal CRISPR/Cas9 components allow multicolor detection of genomic loci with high spatial resolution, which provides an avenue for barcoding elements of the human genome in the living state.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.