Method and apparatus for detecting nanoparticles and biological molecules
US12098991B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Sep 17, 2018 |
| Grant date | Sep 24, 2024 |
| Priority date | — |
| Expiry date | Jul 9, 2040 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG06T2207/10056
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Disclosed are an optical interferometry apparatus for detection of dielectric nanoparticles and a method for enhancing visibility of the nanoparticles. An imaging system for detection of dielectric nanoparticles includes at least one light source for illumination, a detector array or a camera for image capture, an objective lens, a sample substrate and a computing unit. The sample substrate is capable of carrying sub-wavelength particles smaller than the diffraction resolution limit of the imaging system, and the imaging system includes a movable means which moves the sample substrate in the axial direction such that depthwise different images are captured at different axial distances from the sample substrate to the objective lens. The computing unit computes a correlation image using the depth images wherein the sub-wavelength particles become resolvable and appear with higher contrast in the correlation image.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.