Combined radiation acoustics and ultrasound for radiotherapy guidance and cancer targeting

US12102843B2 · kind B2 · utility

Assignee

• THE REGENTS OF THE UNIVERSITY OF MICHIGAN · US

Inventors

• Issam El Naqa · Ann Arbor, US
• Xueding Wang · Ann Arbor, US
• Paul Carson · Ann Arbor, US
• Kyle Cuneo · Ann Arbor, US
• Jean Moran · Ann Arbor, US
• Wei Zhang · Jingwei, CN
• Ibrahim Oraiqat · Ann Arbor, US

Key dates

• Filing date: May 11, 2020
• Grant date: Oct 1, 2024
• Expiry date: Oct 1, 2041

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61N2005/1058
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

A method and system for performing online adapted radiotherapy are provided using combined ultrasound and ionizing radiation induced acoustic imaging (iRAI) computed tomography imaging techniques that can be used for measurement of low to ultrahigh dose deliveries (>40 Gy/s). Multiplexed transducers detect US and iRAI signals allowing for anatomical/functional imaging and radiation mapping with absolute dosimetry measurements of a region of interest during a radiotherapy session. Corrections to radiation dosage intensities and locations is determined and provided as feedback to a radiation source to improve the accuracy of applied radiation dosages intra- or inter-radiotherapy treatment sessions preventing the irradiation of healthy tissues and ensuring the accurate delivery of radiation to a tumor or region of interest.