Analysis systems with microfluidic devices, microfluidic devices and related methods

US12103003B2 · kind B2 · utility

Assignee

• The University of North Carolina at Chapel Hill · US

Inventors

• William Hampton Henley · Chapel Hill, US
• Adam D. Pfefferle · Durham, US
• John Michael Ramsey · Chapel Hill, US
• Ellen Foot Perkowski · Chapel Hill, US

Key dates

• Filing date: Nov 5, 2019
• Grant date: Oct 1, 2024
• Expiry date: Mar 22, 2042

Classification

• Technology area (CPC B): Performing Operations; Transporting
• CPC primary: B01L2400/0487
• WIPO field: Chemical engineering
• WIPO sector: Chemistry

Abstract

Analysis systems with a housing having a chamber sized and configured to receive at least one microfluidic device. The systems also include an optic system coupled to the housing in optical communication with the at least one microfluidic device, a controller coupled to the optic system, a heat source coupled to the optic system and thermally coupled to the at least one microfluidic device held in the housing, and a sub-array selection module in communication with the controller. The sub-array selection module is configured to select a sub-set of sets of microwells of at least one fluid channel of the microfluidic device for imaging by the optic system after a reaction step (e.g., one thermocycle) during an assay.