Compositions and methods for synthesizing 5′-capped RNAs
US12103944B2 · kind B2 · utility
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Key dates
| Filing date | Jan 9, 2024 |
| Grant date | Oct 1, 2024 |
| Priority date | — |
| Expiry date | Jan 9, 2044 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Y207/07
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Provided herein are methods and compositions for synthesizing 5′Capped RNAs wherein the initiating capped oligonucleotide primers have the general form m7Gppp[N2′Ome]n[N]m wherein m7G is N7-methylated guanosine or any guanosine analog, N is any natural, modified or unnatural nucleoside, “n” can be any integer from 0 to 4 and “m” can be an integer from 1 to 9.
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