FGF2 polypeptide with improved temperature stability and protease resistance and use thereof
US12103953B2 · kind B2 · utility
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Key dates
| Filing date | Nov 16, 2020 |
| Grant date | Oct 1, 2024 |
| Priority date | — |
| Expiry date | Sep 12, 2041 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Provided is a polypeptide having FGF2 activity and improved temperature stability and protease resistance. The polypeptide includes at least one substitution selected from a substitution of aspartic acid (D) with glutamic acid (E) at position 28, a substitution of cysteine (C) with isoleucine (I) or leucine (L) at position 78, or a substitution of cysteine (C) with isoleucine (I) or tryptophan (W) at position 96 in SEQ ID NO: 1.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.