Methods of isolating allergen-specific antibodies from humans and uses thereof

US12103964B2 · kind B2 · utility

Assignees

• CZ Biohub SF, LLC · US
• The Board of Trustees of the Leland Stanford Junior · US

Inventors

• Derek Croote · Stanford, US
• Stephen R. Quake · Pasadena, US
• Kari C. Nadeau · Los Altos Hills, US
• Spyros Darmanis · San Francisco, US
• David N. Cornfield · Stanford, US

Key dates

• Filing date: May 17, 2019
• Grant date: Oct 1, 2024
• Expiry date: Oct 17, 2041

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/92
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

In one aspect, methods of generating human monoclonal antibodies that specifically binds to an allergen are provided. In some embodiments, the monoclonal antibodies are generated from sequences identified from isolated single B cells from a human subject who is allergic to the allergen.