Compositions and methods for treating viral infections targeting TRIM7

US12104181B2 · kind B2 · utility

Assignee

• The Board of Regents of the University of Texas System · US

Inventors

• John W. Schoggins · Dallas, US
• Wenchun Fan · Dallas, US
• Daniel J. SIEGWART · Dallas, US
• Qiang Cheng · Shanghai, CN

Key dates

• Filing date: Mar 31, 2022
• Grant date: Oct 1, 2024
• Expiry date: Apr 3, 2042

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2740/16043
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Embodiments of the instant disclosure relate to novel antiviral compositions and methods for treating viral infections. In accordance with these embodiments, antiviral compositions can include at least one mRNA encoding for a TRIM7 protein encapsulated into a lipid nanoparticle (LNP). In other embodiments, methods of making antiviral compositions are disclosed as well as methods of administering a composition having at least one mRNA encoding for a TRIM7 protein encapsulated into LNP into a subject.