Patent · US Active

Transgenic animal having CREBBP gene into which mutation has been introduced

US12108746B2 · kind B2 · utility

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0References

3Claims

0Family size

Assignee

KURUME UNIVERSITY · JP

Inventors

Takahiro SATO · Kurume, JP
Masayasu Kojima · Toyonaka, JP
Kanae Oishi · Kurume, JP

Key dates

Filing date	Jun 28, 2019
Grant date	Oct 8, 2024
Priority date	—
Expiry date	Sep 30, 2041

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12Q2600/156
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

The disclosure provides a non-human transgenic animal having at least one CREBBP gene locus into which a mutation has been introduced, wherein the mutated CREBBP gene encodes a mutant CREBBP consisting of an amino acid sequence having at least 90% identity with the amino acid sequence of SEQ ID NO: 5. The disclosure also provides a method of producing the transgenic animal comprising introducing a mutation into at least one CREBBP gene locus of a non-human animal. The disclosure further provides use of the transgenic animal as a model of Rubinstein-Taybi syndrome or advanced sleep phase syndrome.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.