Pharmaceutical compositions and combinations comprising inhibitors of the androgen receptor and uses thereof
US12109179B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Mar 27, 2020 |
| Grant date | Oct 8, 2024 |
| Priority date | — |
| Expiry date | Apr 14, 2040 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P5/26
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present disclosure generally relates to pharmaceutical compositions and combinations comprising an androgen receptor N-terminal domain inhibitor or an inhibitor and a second therapeutically active agent, such as an CDK4/6 inhibitor, a Pin1 inhibitor (inhibitor of peptidyl-prolyl cis/trans isomerases), or an antiandrogen. In particular, the present disclosure relates to pharmaceutical compositions and combinations useful for treatment of various cancers, for example breast cancer and prostate cancer. Further, the present disclosure relates administering an androgen receptor N-terminal domain inhibitor in combination with radiation therapy for treatment of various cancers.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.