Oral patch for treating mouth ulcers
US12109304B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Nov 28, 2023 |
| Grant date | Oct 8, 2024 |
| Priority date | — |
| Expiry date | Nov 28, 2043 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P17/02
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides an oral patch for localized treatment of mouth ulcers containing combination of tetracaine and triamcinolone as active drugs. The patch is a bilayer structure containing a drug layer with amorphous tetracaine hydrochloride and amorphous triamcinolone acetonide and a water-soluble backing layer without a drug. The oral patch with combination of drugs has improved efficacy over each individual drug. The drug layer comprises 3-20% by weight of amorphous tetracaine hydrochloride, or a pharmaceutical acceptable salt thereof, 0.1-2.0% by weight of amorphous triamcinolone acetonide or a pharmaceutical acceptable salt thereof, 20-95% by weight of a first film-forming material, 1-12% by weight of an adhesive, 1-20% by weight of one or more cooling agent, and optionally 1-12% by weight of a plasticizer. The backing layer comprises 70-95% by weight of one or more film-forming agents, 2-10% by weight of a plasticizer and optionally 1-8% by weight of a flavoring agent.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.