Heterocyclic compounds, preparation methods and uses thereof

US12110289B2 · kind B2 · utility

Assignee

• INVENTISBIO CO., LTD. · CN

Inventors

• Xing Dai · Cranford, US
• Yaolin Wang · Short Hills, US
• Yueheng Jiang · Shanghai, CN
• Yanqin LIU · Shanghai, CN
• Zhe SHI · Shanghai, CN
• Zhenwu Wang · Shanghai, CN
• Liangshan TAO · Shanghai, CN
• Zixing HAN · Shanghai, CN
• Haotao NIU · Shanghai, CN
• Jifang WENG · Shanghai, CN

Key dates

• Filing date: Jul 1, 2021
• Grant date: Oct 8, 2024
• Expiry date: Aug 26, 2042

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D519/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided herein are novel compounds, for example, compounds having a Formula (I) or Formula (II), or a pharmaceutically acceptable salt thereof. Also provided herein are methods of preparing the compounds and methods of using the compounds, for example, in inhibiting KRAS G12C in a cell, and/or in treating various cancer such as pancreatic cancer, endometrial cancer, colorectal cancer, or lung cancer (e.g., non-small cell lung cancer).