Engineered purine nucleoside phosphorylase variant enzymes
US12110493B2 · kind B2 · utility
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10Claims
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Key dates
| Filing date | Sep 30, 2021 |
| Grant date | Oct 8, 2024 |
| Priority date | — |
| Expiry date | Oct 30, 2041 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Y204/02001
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention provides engineered purine nucleoside phosphorylase (PNP) enzymes, polypeptides having PNP activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. Methods for producing PNP enzymes are also provided. The present invention further provides compositions comprising the PNP enzymes and methods of using the engineered PNP enzymes. The present invention finds particular use in the production of pharmaceutical compounds.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.