Thermostable terminal deoxynucleotidyl transferase
US12110516B2 · kind B2 · utility
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23Claims
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Key dates
| Filing date | May 11, 2021 |
| Grant date | Oct 8, 2024 |
| Priority date | — |
| Expiry date | May 11, 2041 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/35
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Disclosed herein include recombinant terminal deoxynucleotidyl transferases (TdTs). In some embodiments, the recombinant TdT comprises an amino acid sequence that is at least 80% identical to a bovine TdT, wherein the recombinant TdT comprises one or more amino acid substitution mutations at one or more positions functionally equivalent to Glu191, Lys193, Glu194, Asp242, Lys287, Phe296, Met299, Thr342, and His421 in the bovine TdT.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.