N-acetylcysteine compositions and methods

US12115244B2 · kind B2 · utility

Assignee

• Endo Operations Limited · IE

Inventors

• Ronald Domalaon · Raritan, US
• Jinjiang Li · Xiamen, CN
• Tushar Hingorani · Bound Brook Junction, US
• Kumaresh Soppimath · Colts Neck Township, US

Key dates

• Filing date: Jul 26, 2023
• Grant date: Oct 15, 2024
• Expiry date: Jul 26, 2043

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61J1/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Storage stable sterile ready-to-administer formulations comprising N-acetylcysteine are presented with desirable stability characteristics. In preferred aspects, formulations comprise low quantities of one or more chelating agents, contain N-acetylcysteine at a concentration of 25 mg/mL or 50 mg/mL, and are packaged in a suitable format, such as a polymeric bag with a metalized overwrap and a non-contact oxygen scavenger.