Structured orodispersible films

US12115247B2 · kind B2 · utility

Assignee

• LTS Lohmann Therapie-Systeme AG · DE

Inventors

• Denise Steiner · Evanston, US
• Arno Kwade · Wendeburg, DE

Key dates

• Filing date: Feb 16, 2018
• Grant date: Oct 15, 2024
• Expiry date: Sep 1, 2038

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K47/38
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed is a method for producing a porous orodispersible film, having the following steps: i) forming a suspension of a pharmaceutically acceptable solvent, a pharmaceutically acceptable matrix material, and a pharmaceutically acceptable binder, said solvent being selected such that the pharmaceutically acceptable matrix material substantially does not dissolve in it, whereas the pharmaceutically acceptable binder is dissolved in the solvent, ii) casting the suspension onto a neutral support, thereby forming a wet film, and iii) drying the wet film and obtaining a dry film. The films produced in this manner have a closed surface on the lower face whereas the upper face is porous, thereby allowing the application of a pharmaceutically active ingredient in the form of a suspension or a solution for example. This allows the active ingredient quantity to be adjusted individually to the particular application and produces a film base material which is suitable for the application of different active ingredients.