Multi-target treatment planning and delivery and virtual localization for radiation therapy

US12115386B2 · kind B2 · utility

Assignee

• RefleXion Medical, Inc. · US

Inventors

• Yevgen VORONENKO · San Jose, US
• Debashish Pal · Sunnyvale, US
• David Q. Larkin · Menlo Park, US
• George Zdasiuk · Portola Valley, US
• Jayakrishnan Janardhanan · Union City, US
• Michael Kirk Owens · San Francisco, US
• Peter Demetri Olcott · Los Gatos, US

Key dates

• Filing date: Jan 7, 2022
• Grant date: Oct 15, 2024
• Expiry date: Sep 14, 2042

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61B6/037
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

Disclosed herein are methods for patient setup and patient target region localization for the irradiation of multiple patient target regions in a single treatment session. Virtual localization is a method that can be used to register a patient target region without requiring that the patient is physically moved using the patient platform. Instead, the planned fluence is updated to reflect the current location of the patient target region by selecting a localization reference in the localization image, calculating a localization function based on the localization reference point, and calculating the delivery fluence by convolving the localization function with a shift-invariant firing filter. Mosaic multi-target localization partitions a planned fluence map for multiple patient target regions into sub-regions that can be individually localized. De-coupled multi-target localization involves generating a separate planned fluence map for each target but constraining a cumulative fluence map to ensure dosimetric goals are met.