Method for preparing brivaracetam and intermediate thereof

US12116342B2 · kind B2 · utility

Assignees

• ZHEJIANG HUAHAI PHARMACEUTICAL CO., LTD. · CN
• Shanghai Syncores Technologies Inc. Ltd. · CN

Inventors

• Haisheng Fan · Shanghai, CN
• Yipeng ZHAN · Shanghai, CN
• Kai YIN · Shanghai, CN
• Xiang JI · Suzhou, CN
• Fenghao Liu · Shanghai, CN
• Kaiqiang Shi · Shanghai, CN
• Xiaowen Guo · Shanghai, CN
• Luning Huang · Shanghai, CN
• Anping Tao · Shanghai, CN
• Jianguo An · Shanghai, CN
• Hong Gu · Dongguan, CN

Key dates

• Filing date: Dec 12, 2019
• Grant date: Oct 15, 2024
• Expiry date: Jan 15, 2042

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07B2200/13
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present application relates to a method (I) for preparing a brivaracetam intermediate, comprising the steps of dissolving the compound represented by B-P and 1S,2S-diphenylethylenediamine in a solvent for resolution, crystallizing, filtering, and recrystallizing to obtain the compound represented by B-Q, which is then converted to the brivaracetam intermediate represented by B-R. This method can effectively resolve the compound represented by B-P. The present application also provides a method for preparing brivaracetam using the compound represented by B-R. The method can separate the effective components only through simple steps such as extraction, washing, drying, and concentration without requiring use of chiral chromatography column to separate isomers in the preparation process, and thus the separation process is simple, greatly reducing the production cost of brivaracetam.