Low-temperature continuous-flow preparation method of bedaquiline
US12116345B2 · kind B2 · utility
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Key dates
| Filing date | May 21, 2024 |
| Grant date | Oct 15, 2024 |
| Priority date | — |
| Expiry date | May 21, 2044 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB01J2219/00033
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A low-temperature continuous-flow preparation method of bedaquiline includes the following steps. (a) A first feed liquid and a second feed liquid are subjected to a first continuous flow reaction for 30-600 seconds to obtain a first reaction mixture. (b) The first reaction mixture and a third feed liquid are subjected to a second continuous flow reaction for 30-600 seconds to obtain a second reaction mixture. (c) The second reaction mixture was quenched to afford bedaquiline.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.