Methods of screening compounds
US12117442B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jun 22, 2023 |
| Grant date | Oct 15, 2024 |
| Priority date | — |
| Expiry date | Jun 22, 2043 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2500/04
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Disclosed herein are methods of screening candidate binding compounds to a plurality of target nucleic acids either of the same sequence or of different sequences utilizing a device configured to detect changes in the folding and unfolding force of the target nucleic acid upon binding to various candidate binding compounds. In the presence of a plurality of nucleic acid sequences, the methods described herein also can rapidly determine the specificity of the small molecule or polypeptide to a nucleic acid structure. Also, disclosed herein are methods of measuring binding kinetics of binding compounds to a target nucleic acid using a device configured to detect changes in the folding and unfolding force of the target nucleic acid upon binding to varying concentrations of the candidate binding compound.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.