Allosteric enhancing compound of GABAA receptor and preparation and use thereof

US12121498B2 · kind B2 · utility

Assignee

• XI'AN LIBANG ZHAOXIN BIOTECHNOLOGY CO., LTD · CN

Inventors

• Rutao Wang · Tuji, CN
• Long An · Xi'an, CN
• Yi Zhao · South Pasadena, US
• Jinghua Pang · Xi'an, CN
• Tao Chen · 安丰镇, CN
• Weijiao Wang · Tuji, CN

Key dates

• Filing date: Jul 10, 2019
• Grant date: Oct 22, 2024
• Expiry date: Nov 23, 2040

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C39/15
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure provides an allosteric enhancing compound of GABAA receptors or a prodrug thereof, a method for preparing the same, and use thereof. The compound is represented by formula (1), wherein R1 and R2 are each independently selected from isopropyl or n-propyl; and when R1 is n-propyl, R2 is not isopropyl.