Methods and compositions for CNS delivery of iduronate-2-sulfatase
US12121569B2 · kind B2 · utility
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15References
15Claims
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Key dates
| Filing date | Jan 18, 2022 |
| Grant date | Oct 22, 2024 |
| Priority date | — |
| Expiry date | Jan 18, 2042 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Y310/01001
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides, among other things, compositions and methods for CNS delivery of lysosomal enzymes for effective treatment of lysosomal storage diseases. In some embodiments, the present invention includes a stable formulation for direct CNS intrathecal administration comprising an iduronate-2-sulfatase (I2S) protein, salt, and a polysorbate surfactant for the treatment of Hunters Syndrome.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.