Blood coagulation-promoting silk fibroin-polypeptide electrospun membrane and preparation method thereof
US12121626B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Dec 5, 2021 |
| Grant date | Oct 22, 2024 |
| Priority date | — |
| Expiry date | Apr 24, 2043 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61L2400/04
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
The present invention discloses a blood coagulation-promoting silk fibroin-polypeptide electrospun membrane and a preparation method thereof. The electrospun membrane is made by using silkworm silk fibroin as a carrier and adding the polypeptide GPRPPSEHLQIT. It is mainly used for promoting blood coagulation, and is a blood coagulation material that can targetedly bind to human fibrinogen. The preparation method includes the steps of dissolving, filtering, dialyzing, concentrating and freeze-drying silkworm cocoons after degumming to obtain silk fibroin freeze-dried powder. The polypeptide used in the present invention is a polypeptide obtained by self-screening. Compared with other polypeptides, it can specifically targetedly bind to human fibrinogen.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.