Patent · US Active

Life-cycle-defective adenovirus helper viruses, their production and use for producing rAAV

US12123027B2 · kind B2 · utility

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0References

22Claims

0Family size

Assignee

Ascend Advanced Therapies Limited · GB

Inventors

Markus Horer · Martinsried, DE
Stefan Kochanek · Ulm, DE
Caroline Hauser · Ehingen, DE
Alexandra Krüger-Haag · Blaustein, DE

Key dates

Filing date	Oct 12, 2018
Grant date	Oct 22, 2024
Priority date	—
Expiry date	Jun 11, 2041

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2750/14152
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The invention generally concerns the production of defective Adenovirus helper viruses for producing a recombinant adeno-associated virus (rAAV), wherein the Adenovirus helper virus contains at least one mutation selected from (a) an inactivating mutation in the transcription unit coding for the L4-100K protein; (b) an inactivating mutation in the transcription unit coding for the L1-52/55K protein; (c) an inactivating mutation in the transcription unit coding for the preterminal protein (pTP); (d) a mutation in the L4-100K protein in order to render it temperature-sensitive (ts); (e) a mutation in the hexon protein in order to render it temperature-sensitive (ts); and/or (f) a mutation in the L4-00K protein and a mutation in the hexon protein in order to render it temperature-sensitive (ts).

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.