Patent · US Active

Modified double-stranded donor templates

US12123033B2 · kind B2 · utility

0Cited by

1References

7Claims

0Family size

Assignee

INTEGRATED DNA TECHNOLOGIES, INC. · US

Inventors

Jessica Woodley · North Liberty, US
Bernice Thommandru · Iowa City, US
Joseph Dobosy · Coralville, US
Mark Aaron Behlke · Coralville, US
Adam Clore · Iowa City, US
Garrett Richard Rettig · Coralville, US
Beimeng Sun · North Liberty, US

Key dates

Filing date	Oct 23, 2020
Grant date	Oct 22, 2024
Priority date	—
Expiry date	Jan 1, 2041

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2800/80
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

Described herein are compositions and methods for improving homology directed repair (HDR) efficiency and reducing homology-independent integration following introduction of double strand breaks with engineered nucleases. Additionally, modifications to double stranded DNA donors to improve the donor potency and efficiency of homology directed repair following introduction of double stranded breaks with programmable nucleases.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.