Genetically modified cells that produce C6-C10 fatty acid derivatives

US12123045B2 · kind B2 · utility

Assignee

• CARGILL, INCORPORATED · US

Inventors

• Hans H. Liao · Plymouth, US
• Catherine Bradshaw POOR · Boulder, US
• Travis Robert Wolter · Denver, US
• Michael Louie · Plymouth, US
• Erin Kathleen MARASCO · Excelsior, US
• Ana Negrete-Raymond · Roseville, US

Key dates

• Filing date: May 2, 2022
• Grant date: Oct 22, 2024
• Expiry date: Jul 21, 2042

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Y203/01199
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

Genes encoding mutant 3-ketoacyl-CoA synthases are introduced into host cells. Certain of the mutants enhance the production of shorter-chain fatty acids and derivatives by the cell than do the wild-type (unmutated) enzymes. In other cases, the chain length is not significantly affected, but productivity is enhanced. In specific cases, both a shift toward lower chain length and higher productivity is seen. Cells producing the mutant 3-ketoacyl-CoA synthases are especially suitable for producing C6-C10 fatty acids and derivatives.