Methods for measuring ubiquitin carboxy—terminal hydrolase L1 levels in blood
US12123883B2 · kind B2 · utility
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15Claims
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Key dates
| Filing date | Sep 30, 2021 |
| Grant date | Oct 22, 2024 |
| Priority date | — |
| Expiry date | Feb 13, 2042 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/60
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Disclosed herein are improved methods of processing, measuring, and detecting levels of ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) in blood samples taken from a human subject at time points within about 8 hours (or about 8 hours or less) after obtaining the sample from the subject. UCH-L1 is an early biomarker for traumatic brain injury (TBI), and there is a need for improved methods for assessing UCH-L1 in blood can aid in the diagnosis and evaluation of a human subject who has sustained or may have sustained a head injury.
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