Transglutaminase conjugation method and linker
US12128110B2 · kind B2 · utility
0Cited by
23References
31Claims
0Family size
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Key dates
| Filing date | Sep 19, 2018 |
| Grant date | Oct 29, 2024 |
| Priority date | — |
| Expiry date | Nov 12, 2040 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2317/41
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to a method for generating an antibody-payload conjugate by means of a microbial transglutaminase (MTG). The method comprises a step of conjugating a linker having a primary amine residue, said linker having the peptide structure (shown in N->C direction) (Aax)m-(Aax)(NH2)-(Aax)n-B-(Aax)o, or (Aax)m-B-(Aax)n-(Aax)(NH2)-(Aax)o, to a Gln residue comprised in the heavy or light chain of an antibody. Aax(NH2) is an amino acid, amino acid derivative or amino acid mimetic comprising a side chain having a primary amine group.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.