Compositions and methods for cardiac regeneration

US12128136B2 · kind B2 · utility

Assignee

• The Trustees of the University of Pennsylvania · US

Inventors

• Edward E. Morrisey · Newtown Square, US
• Jason Alan Burdick · Philadelphia, US
• Leo Wang · Shanghai, CN

Key dates

• Filing date: Apr 2, 2018
• Grant date: Oct 29, 2024
• Expiry date: Apr 2, 2038

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P9/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure provides microRNA-based therapies using a hydrogel delivery system that provides regenerative approach to myocardial infarction by targeting cardiomyocytes. The hydrogel provides for local and sustained cardiac delivery of microRNAs, such miR-302 mimics that can be used to promote cardiomyocyte proliferation. Also provided are compositions suitable for local and sustained release and methods for intramyocardial gel delivery of a miRNA oligonucleotide.