Methods, processes, and compositions for improved preparation of HU308 and HU433
US12129227B2 · kind B2 · utility
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20Claims
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Inventors
Key dates
| Filing date | Sep 23, 2021 |
| Grant date | Oct 29, 2024 |
| Priority date | — |
| Expiry date | Sep 23, 2041 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C2602/42
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Disclosed herein are methods, processes and compositions for preparing a compound of formula 8: (8), and formula 18: (18). The methods and processes comprise performing a first allylic oxidation, a protection reaction, a second allylic oxidation, a reduction reaction, performing an acid-catalyzed coupling reaction, a methylation reaction and a deprotection reaction. Disclosed herein are methods, processes and compositions for enantioselectively preparing compounds of formulae 8 and 18. Also disclosed herein are compositions comprising compounds of formulae 8, 18 and/or intermediates and/or starting material thereof.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.