Patent · US Active

Methods for ethanol-free mRNA purification

US12129460B2 · kind B2 · utility

0Cited by

12References

21Claims

0Family size

Assignee

Sanofi · FR

Inventors

Eric Calvosa · Tarare, FR
Nicolas Chaudet · Paris, FR
Arthur LECLERCQ · Paris, FR
Alban LEPETITCOLIN · Paris, FR

Key dates

Filing date	Jul 28, 2023
Grant date	Oct 29, 2024
Priority date	—
Expiry date	Jul 28, 2043

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N9/52
WIPO fieldChemical engineering
WIPO sectorChemistry

Abstract

Provided herein are methods of purifying messenger RNA (mRNA) by subjecting a preparation comprising in vitro synthesized mRNA to one or more steps of enzymatic digestion with a proteinase, optionally with a further oligo dT affinity chromatography step. Also provided are mRNA purified by the methods described herein.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.