T7 RNA polymerase variants
US12129494B2 · kind B2 · utility
0Cited by
152References
17Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Dec 21, 2021 |
| Grant date | Oct 29, 2024 |
| Priority date | — |
| Expiry date | Dec 21, 2041 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N15/00
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention provides engineered RNA polymerase variants and compositions comprising these variants. The present invention further provides engineered T7 RNA polymerase variants and compositions comprising these variants. These variants have been evolved for selective incorporation of the m7G(5′)ppp(5′)m7G cap analog over GTP at the initiation of in vitro transcription. The present invention also provides methods for selective capping of RNA transcripts.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.