Methods for detection of macro-heteroplasmy and micro-heteroplasmy in mitochondrial DNA
US12129521B2 · kind B2 · utility
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Key dates
| Filing date | Oct 23, 2020 |
| Grant date | Oct 29, 2024 |
| Priority date | — |
| Expiry date | Dec 19, 2040 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q2600/156
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present disclosure provides methods for detecting macro-heteroplasmy and/or micro-heteroplasmy in mitochondrial DNA. The methods can include detecting or monitoring the presence of heteroplasmy, and/or identifying a threshold level of heteroplasmy. In addition, the methods can be used for diagnosing a mitochondrial related disease or disorder, as well as for monitoring the efficacy of a therapy affecting mitochondrial DNA (mtDNA) in a subject having or suspected of having heteroplasmy.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.