Function guided in silico protein design
US12131801B2 · kind B2 · utility
Inventors
Key dates
| Filing date | Nov 17, 2023 |
| Grant date | Oct 29, 2024 |
| Priority date | — |
| Expiry date | Nov 17, 2043 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG16B15/20
- WIPO fieldComputer technology
- WIPO sectorElectrical engineering
Abstract
A protein design system includes one or more processors configured to modify, by a modifier, an input sequence corresponding to a protein, the input sequence comprising a data structure indicating a plurality of amino acid residues of the protein; map, by an encoder, the modified sequence to a latent space; predict, by a length predictor, a length difference between the mapped sequence and a target sequence based on at least one target function of the target sequence; identify, by a function classifier, at least one sequence function of the modified sequence; transform, by a length transformer, the modified sequence based on the length difference and the at least one sequence function; and generate, by a decoder, a candidate for the target sequence based on the transformed sequence.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.