Method for the manufacture of 3-[(1S)-1-imidazo[1,2-a]pyridin-6-ylethyl]-5-(1-methylpyrazol-4-yl)triazolo[4,5-b]pyrazine and polymorphic forms thereof

US12134613B2 · kind B2 · utility

Assignees

• ASTRAZENECA AB · SE
• HUTCHISON MEDIPHARMA LIMITED · CN

Inventors

• Andrew Turner · Macclesfield, GB
• Andrew Turner · Macclesfield, GB
• Gareth Howell · Bar Harbor, US
• Malcolm Allan Young Gall · Cambridge, GB
• Keith Raymond Mulholland · Harlow, GB
• Neil Keith Adlington · Cambridge, GB
• Zhenping Tian · Shandong, CN
• Bo Liu · San Diego, US
• Qisun Gong · Shanghai, CN
• Wei Yu · Taichung, TW

Key dates

• Filing date: Sep 10, 2019
• Grant date: Nov 5, 2024
• Expiry date: May 21, 2041

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D519/00
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

This specification generally relates to an improved method for the manufacture of 3-[(1S)-1-imidazo[1,2-a]pyridin-6-ylethyl]-5-(1-methylpyrazol-4-yl)triazolo[4,5-b]pyrazine (I), or pharmaceutically acceptable salts thereof; polymorphic forms thereof, and intermediates useful in the manufacture of such compounds and salts thereof.