MART-1(27-35) epitope-specific T cell receptor

US12134637B2 · kind B2 · utility

Assignee

• BGI SHENZHEN · CN

Inventors

• Fei Wang · Beijing, CN
• Chengchi Chao · Longbeilingcun, CN
• Bo Li · San Jose, US
• Yong Hou · Tangxia, CN
• Yuelu Yin · Lo Wu, CN
• Shilei Wang · Lo Wu, CN
• Kun Duan · Lo Wu, CN

Key dates

• Filing date: Jul 12, 2018
• Grant date: Nov 5, 2024
• Expiry date: Jan 26, 2041

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2740/16043
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided is a MART-1 (27-35) epitope-specific T cell receptor, comprising an α chain and a β chain. The α chain comprises three complementary determining regions, respective sequences thereof being positions 61-66, positions 84-89, and positions 124-136 of SEQ ID No. 3. The β chain comprises three complementary determining regions, respective amino acid sequences thereof being positions 46-50, positions 68-73, and positions 112-125 of SEQ ID No. 4. A T cell expressing the TCR can effectively recognize a MART-1 (27-35) epitope polypeptide supported on a T2 cell and secrete IFN-γ, thereby demonstrating the functionality of the receptor. Use of the TCR with a relevant drug target allows for effective drug development.