Dickkopf-1 variant antibodies and methods of use

US12134656B2 · kind B2 · utility

Assignee

• Twist Bioscience Corporation · US

Inventors

• Aaron Sato · Somerville, US
• Tom YUAN · South San Francisco, US
• Linya Wang · Milpitas, US
• Fumiko Takada Axelrod · Palo Alto, US

Key dates

• Filing date: Nov 17, 2022
• Grant date: Nov 5, 2024
• Expiry date: Nov 17, 2042

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/92
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided herein are methods and compositions relating to libraries of optimized antibodies having nucleic acids encoding for an antibody comprising modified sequences. Libraries described herein comprise nucleic acids encoding Dickkopf WNT signaling pathway inhibitor 1 (DKK1) antibodies. Further described herein are protein libraries generated when the nucleic acid libraries are translated. Further described herein are cell libraries expressing variegated nucleic acid libraries described herein.