Methods of detecting a leak from a subarray of a microarray chip, kits of components that facilitate leak detection, and microarray chips configured for leak detection
US12134798B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Dec 6, 2023 |
| Grant date | Nov 5, 2024 |
| Priority date | — |
| Expiry date | Dec 6, 2043 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB01L2300/168
- WIPO fieldChemical engineering
- WIPO sectorChemistry
Abstract
Methods of detecting a leak from a subarray of a microarray chip, kits of components that facilitate leak detection, and microarray chips configured for leak detection are disclosed herein. The methods include positioning, within the given subarray, a sample solution, which includes dissolved sample molecules (DSMs) that define a dissolved sample oligonucleotide sequence and dissolved leak detection molecules (DLDMs) that define a predetermined dissolved leak detection oligonucleotide sequence. The methods also include detecting the DLDMs within a region of the microarray chip that is external the given subarray. The kits of components include the microarray chip and DLDMs. The microarray chips includes a plurality of subarrays and a leak detection region that is at least partially external the plurality of subarrays.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.