Peptide quantitation assay for differentiating full-length high molecular weight kininogen (HMWK) and cleaved HMWK
US12135329B2 · kind B2 · utility
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17Claims
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Key dates
| Filing date | Apr 28, 2023 |
| Grant date | Nov 5, 2024 |
| Priority date | — |
| Expiry date | Apr 28, 2043 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/50
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Methods for differentiating full-length high molecular weight kininogen (HMWK) and cleaved HMWK in a sample are provided herein. Such methods may comprise treating a biological sample with a protease to generate a plurality of digested peptides, and measuring one or more signature peptides, which are indicative of cleaved HMWK and/or full-length HMWK.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.