Gastroretentive articles for alcohol sensing

US12138034B2 · kind B2 · utility

Assignees

• Massachusetts Institute of Technology · US
• The Brigham and Women's Hospital, Inc. · US
• The General Hospital Corporation · US

Inventors

• Robert S. Langer · Newton, US
• Carlo Giovanni Traverso · Newton, US
• Malvika Verma · Cambridge, US
• Feyisope Eweje · Boston, US
• Christoph Winfried Johannes Steiger · Oberasbach, DE
• Junwei Li · Beijing, CN
• Nhi Phan · Somerville, US
• Hen-Wei Huang · Cambridge, US
• Jacqueline Chu · Boston, US
• John Ashraf Fou Salama · Cambridge, US

Key dates

• Filing date: Dec 15, 2023
• Grant date: Nov 12, 2024
• Expiry date: Dec 15, 2043

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A90/10
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

Drug delivery articles, resident articles, and retrieval systems e.g., for gram-level dosing, are generally provided. In some embodiments, the residence articles are configured for transesophageal administration, transesophageal retrieval, and/or gastric retention to/in a subject. In certain embodiments, the residence article includes dimensions configured for transesophageal administration with a gastric resident system. In some cases, the residence article may be configured to control drug release e.g., with zero-order drug kinetics with no potential for burst release for weeks to months. In some embodiments, the residence articles described herein comprise biocompatible materials and/or are safe for gastric retention. In certain embodiments, the residence article includes dimensions configured for transesophageal retrieval. In some cases, the residence articles described herein may comprise relatively large doses of drug (e.g., greater than or equal to 1 gram).