Patent · US Active

Pharmaceutical composition for oral administration comprising aminopyrimidine derivative or pharmaceutically acceptable salt, hydrate, or solvate thereof

US12138351B2 · kind B2 · utility

0Cited by

3References

28Claims

0Family size

Assignee

JANSSEN BIOTECH, INC. · US

Inventors

Jacqueline Maximilien · Ekeren, BE
Gopal Rajan · Ekeren, BE

Key dates

Filing date	Apr 13, 2021
Grant date	Nov 12, 2024
Priority date	—
Expiry date	Apr 13, 2041

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07B2200/13
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Provided herein are pharmaceutical compositions for oral administration comprising N-(5-(4-(4-((dimethylamino)methyl)-3-phenyl-1H-pyrazol-1-yl)pirimidine-2-ylamino)-4-methoxy-2-morpholinophenyl)acrylamide or a pharmaceutically acceptable salt, hydrate, or solvate thereof as an active ingredient; and a combination of (i) a cellulose derivative and (ii) a sugar or polyol as diluents. The disclosed compositions are characterized by improved manufacturability, while maintaining the pharmaceutical benefits of minimizing the effect according to changes in pH environment in the stomach, possessing excellent stability, and exhibiting good bioavailability.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.