Extruded hydrogel tubes and coaxial fibers and applications thereof
US12138843B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jun 13, 2019 |
| Grant date | Nov 12, 2024 |
| Priority date | — |
| Expiry date | Jul 9, 2041 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB29K2995/0092
- WIPO fieldOther special machines
- WIPO sectorMechanical engineering
Abstract
Methods of fabricating a hydrogel tube, and related systems, employ extrusion of a cross-linkable hydrogel solution from an annular outer nozzle of a nozzle assembly to form a cross-linkable hydrogel tube. The cross-linkable hydrogel tube is cured to form a cross-linked hydrogel tube. A second hydrogel solution can be coextruded via the axial inner nozzle to form an inner hydrogel filament coaxially positioned within the cross-linkable hydrogel tube. The cross-linked hydrogel tube can be functionalized with collagen to enable cell adhesion, and cells can be cultured on the luminal surfaces of these tubes to yield tubular endothelial layers. A 3D printed coaxial nozzle can be used to fabricate biofunctional tubular conduits that can be utilized for engineering in vitro models of tubular biological structures.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.