5-thiazolecarboxamide kinase inhibitor and uses thereof

US12139480B2 · kind B2 · utility

Assignee

• IOMX THERAPEUTICS AG · DE

Inventors

• Peter Sennhenn · Munich, DE
• Sebastian Meier-Ewert · Martinsried, DE
• Nisit Khandelwal · Heidelberg, DE

Key dates

• Filing date: Apr 23, 2019
• Grant date: Nov 12, 2024
• Expiry date: Jan 25, 2042

Classification

• Technology area (CPC G): Physics
• CPC primary: G06Q10/08
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to a kinase inhibitor, in particular an inhibitor of protein kinases including the protein-tyrosine kinases LCK, ABL, SRC, KIT, SIK-family and/or their mutants. Although structurally similar to dasatinib, the kinase inhibitor of the invention displays, eg functional and ADMET properties distinct to dasatinib. Also, the invention relates to pharmaceutical compositions that comprise the kinase inhibitor, including those formulated for oral administration, such as in unit dose form that comprise particular ranges or amounts of the kinase inhibitor. The kinase inhibitor or pharmaceutical composition may be used in the treatment of a proliferative disorder, such as a leukaemia or solid tumour. The kinase inhibitor or pharmaceutical composition may be used in a treatment regimen that corresponds to, is similar to or is distinct from that used with dasatinib for a corresponding disorder, and in particular may be used in a combination treatment regimen together with one or more additional therapeutic agents, such as immune-checkpoint inhibitors.