Process for preparing 1-(4-fluorophenyl)-4-((6bR, 10aS)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H-pyrido[3′,4′:4,5]pyrrolo[1,2,3-de]quinoxalin-8(7H)-yl)butan-1-one

US12139490B2 · kind B2 · utility

Assignee

• INTRA-CELLULAR THERAPIES, INC. · US

Inventors

• John Charles Tomesch · Succasunna, US
• Peng Li · New York, US
• Wei Yao · Shanghai, CN
• Qiang Zhang · Dalian, CN
• James David Beard · New York, US
• Andrew S. Thompson · Mountainside, US
• Hua Cheng · Plainsboro, US
• Lawrence P. Wennogle · Fryeburg, US

Key dates

• Filing date: Jun 24, 2022
• Grant date: Nov 12, 2024
• Expiry date: Jan 4, 2043

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides methods for the preparation of substituted heterocycle fused gamma-carbolines, such as the compound of Formula 2J, as shown below, intermediates useful in producing them and methods for producing such intermediates and such heterocycle fused gamma-carbolines, and as further defined herein.