Anti-human vista antibodies and use thereof
US12139532B2 · kind B2 · utility
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14Claims
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Key dates
| Filing date | Apr 17, 2017 |
| Grant date | Nov 12, 2024 |
| Priority date | — |
| Expiry date | Feb 12, 2038 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention provides agonistic anti-human VISTA antibodies and antibody fragments. These agonist antibodies and antibody fragments may be used to potentiate or enhance or mimic VISTA's suppressive effects on T cell immunity and thereby suppress T cell immunity. These agonist antibodies and antibody fragments are especially useful in the treatment of autoimmunity, allergy, inflammatory conditions, GVHD, sepsis and transplant recipients. Screening assays for identifying these agonists are also provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.