Stabilized CRISPR complexes
US12139707B2 · kind B2 · utility
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8Claims
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Key dates
| Filing date | Jul 23, 2021 |
| Grant date | Nov 12, 2024 |
| Priority date | — |
| Expiry date | Aug 5, 2042 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2310/53
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Provided herein are polynucleotides and CRISPR effector proteins configured to be covalently bound together in a CRISPR complex. The polynucleotides can be further modified to modulate the activity of the CRISPR complex. Modification of the polynucleotide and CRISPR effector protein can be used to improve the efficacy of target binding and/or cleavage.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.