Methods of treating EGFRvIII expressing glioblastomas
US12144826B2 · kind B2 · utility
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8Claims
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Key dates
| Filing date | Apr 4, 2019 |
| Grant date | Nov 19, 2024 |
| Priority date | — |
| Expiry date | Mar 12, 2042 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2830/002
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods are provided for treating a subject for an EGFRvIII expressing glioblastoma. The methods of the present disclosure involve administering to the subject a molecular circuit that is primed by EGFRvIII to induce one or more encoded therapeutics specific for one or more antigens expressed by the glioblastoma. Nucleic acids containing sequences encoding all or portions of such circuits are also provided, as well as cells, expression cassettes and vectors that contain such nucleic acids. Also provided are kits for practicing the described methods.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.