Vectors for eliciting immune responses to non-dominant epitopes in the hemagglutinin (HA) protein
US12144857B2 · kind B2 · utility
2Cited by
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14Claims
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Key dates
| Filing date | Jul 18, 2022 |
| Grant date | Nov 19, 2024 |
| Priority date | — |
| Expiry date | Jul 18, 2042 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2760/16134
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods of preparing influenza viruses having altered immunodominant epitopes in HA, e.g., having one or more residues in one or more of antigenic sites A-E in HA altered, and viral vectors, e.g., influenza virus VLPs or non-influenza viruses or VLPs thereof expressing or having influenza HAs with altered immunogenicity as a result of altered immunodominant epitopes therein are provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.