Stabilized formulations of lipid nanoparticles
US12144895B2 · kind B2 · utility
3Cited by
77References
21Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Dec 13, 2022 |
| Grant date | Nov 19, 2024 |
| Priority date | — |
| Expiry date | Jan 6, 2043 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N15/88
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The disclosure features a lipid nanoparticle (LNP) formulation comprising a plurality of LNPs and a stabilizing agent that mitigates the degradation of the LNPs or a subpopulation thereof. Lipid nanoparticles further including therapeutics and/or prophylactics such as RNA are useful in the delivery of therapeutics and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression. Methods of manufacturing LNP formulations and screening for a stabilizing agent are also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.